朱峰, M.D.,Ph.D
Tel:86-18971681230
河南大学淮河医院转化医学中心，第三层次高级人才引进。
研究领域：肿瘤相关的新激酶的功能研究；肿瘤标志物；肿瘤细胞的信号转导。
湖北省“楚天学者”特聘教授，博士生导师
学术任职：
中国医学生物化学与分子生物学理事会理事（第六届）；
中国医学-工程融合学术分会常务理事（第二届）
湖北省生物化学与分子生物学理事
河南省免疫协会理事
评价指标：
H-Index:42
学历：
1996/09-1999/06：第四军医大学，生物化学教研室，博士。
1993/09-1996/06：第四军医大学，生物化学教研室，硕士。
1987/09-1993/06：第四军医大学，生物化学教研室，学士。
工作经历：
教授，河南大学淮河医院转化医学中心 2022.4-今
教授，桂林医学院肿瘤研究所 2019.12-2022.4
“楚天学者”特聘教授，华中科技大学同济医学院 2013.6-2019.12
ResearchAssociate Professor:HormelInstitute, UniversityofMinnesota 2012.6-2013.6
ResearchAssistantProfessor:HormelInstitute,UniversityofMinnesota 2005.4-2012.6
PostdoctoralFellow:Hormel Institute,UniversityofMinnesota 2002.3-2005.4
超英生物。中国，西安。 2001.12-2002.3
Visiting Scientist:InstituteofMolecularandCellularBiology, Singapore 2000.2-2001.11
讲师，第四军医大学生物化学教研室。中国，西安。 1999.9-2000.1
近年研究基金：
1. Src在Y246磷酸化BCAA分解代谢的限速酶BCKDK，促进结直肠癌的转移，国家自然科学基金面上项目，项目批准号：81972762，项目起止年月：2020/01- 2023/12，55万元，主持。
2. c-Met磷酸化TOPK促进非小细胞肺癌对TKI耐药的机理研究，国家自然科学基金面上项目，81672936，
2017/01-2020/12，58万元，主持。
3. Src在Y74、Y272磷酸化TOPK对结肠癌发生的作用及机制研究，国家自然科学基金面上项目，
81472602，2015/01-2018/12，72万元，主持。
4. Akt激活TOPK促进结肠癌的化疗耐药研究，华中科技大学自主创新国际合作2014ZZGH013，10万
5. Src在Y74、Y272磷酸化TOPK对结肠癌发生的作用及机制研究，华中科技大学自主创新前沿探索，
2014TS063，12万
6. 肿瘤靶向治疗的新蛋白激酶靶标确立、其抑制剂及抗体研究，华中科技大学自主创新90万（含80万启动经费）
7. TOPK在肿瘤耐药中的作用机理研究，华中科技大学自主创新2016YXZD034，20万
已授权专利：
1.朱峰; 段秋红; 肖娟娟; 王菲; 一种抗非小细胞肺癌的药物组合物, 2021-1-15, 中国, ZL201811243867.4(专利)
2.朱峰; 段秋红; 肖娟娟; 王哲; 薛佩佩; 孙惠敏; 邵晨; 曾凡帆; 全纯涛; 卢涛; 刘琳; 袁萍;柯昌庶; 熊华; 路慧; 尹燕华; 潘华雄; 一种抗TOPK第74位酪氨酸残基磷酸化的抗体及其制备方法和应用,2016-2-29, 中国, CN201610111135.4(专利)
3.朱峰;段秋红;王菲;张璐;汪薇;肖娟娟：甲基黄连碱用作JNK2抑制剂和治疗银屑病的用途。
201911251923.3
4.朱峰; 段秋红; 王菲; 张璐; 汪薇; 肖娟娟; 山萘苷在制备抗非小细胞肺癌药物中的用途,2021-6-11, 中国,202110653286.3
近年通讯作者的论文：
1.Duan Q, Wang W, Xiong H, Xiao J, Xiao H, Zhu F, Lu H. JAK2/ULK1 axis promotes cervical cancer progression by autophagy induction and SRPK1 phosphorylation. Oncogene. 2025 Mar;44(9):587-600.
2.Wang W, Li Y, Tang L, Shi Y, Li W, Zou L, Zhang L, Cheng Y, Yuan Z, Zhu F, Duan Q. Cross-talk between BCKDK-mediated phosphorylation and STUB1-dependent ubiquitination degradation of BCAT1 promotes GBM progression. Cancer Lett. 2024 Jun 1;591:216849.
3.Wang J, Wang W, Zhu F, Duan Q. The role of branched chain amino acids metabolic disorders in tumorigenesis and progression. Biomed Pharmacother. 2022 Sep;153:113390. doi: 10.1016/j.biopha.2022.113390. Epub 2022 Jul 14. PMID: 36076478.
4.Zou L, Wang W, Huang W, Ni X, Li W, Cheng Y, Tian Q, Liu L, Zhu F, Duan Q. FYN-mediated phosphorylation of BCKDK at Y151 promotes GBM proliferation by increasing the oncogenic metabolite N-acetyl-L-alanine. Heliyon. 2024 Jul 1;10(15):e33663.
5.Lu H, Huang Y, Ni X, Ma T, Chang T, Liu M, Li N, Lu P, Yuan P, Liu L, Shi F, Xiao J, Xiao H, Duan Q, Zhu F. TOPK promotes the development of psoriasis and worenine alleviates psoriasiform dermatitis by inhibiting TOPK activity. J EurAcad Dermatol Venereol. 2024 May;38(5):851-863.
6.LiMY,FanLN,HanDH,YuZ,MaJ,LiuYX,LiPF,ZhaoDH,ChaiJ,JiangL,LiSL,XiaoJJ,DuanQH,YeJ, ShiM,NieYZ,WuKC,LiaoDJ,ShiY,WangY,YanQG,GuoSP,BianXW,ZhuF*,ZhangJ*,WangZ*. RibosomalS6proteinkinase4promotesradioresistanceinesophagealsquamouscellcarcinoma.JClinInvest. 2020 Aug3;130(8):4301-4319. (IF=14.808)
7.TheroleofT-LAKcell-originatedproteinkinaseintargetedcancertherapy.ZhangL, WangF,YiH,ErmakovaSP,Malyarenko OS, Mo J, Huang Y, Duan Q, Xiao J, Zhu F. Mol Cell Biochem. 2022 Mar;477(3):759-769.doi: 10.1007/s11010-021-04329-5. Epub 2022 Jan 17. PMID: 35037144. (IF=3.396)
8.Xiao J, Wang F, Lu H, Xu S, Zou L, Tian Q, Fu Y, Lin X, Liu L, Yuan P, Ni X, Ma T, Zeng F, Xue P, Xiu R, Zhang J,JiX,HuH,LuS,DaiH,LiY,ChuQ,ZhaoX,DuanQ*,ZhuF*.TargetingtheCOX2/MET/TOPKsignaling axis induces apoptosis in gefitinib-resistant NSCLC cells. Cell Death Dis. 2019 Oct 14;10(10):777.(IF=8.469)
9.TianQ,YuanP,QuanC,LiM,XiaoJ,ZhangL,LuH,MaT,ZouL,WangF,XueP,NiX,WangW,LiuL,WangZ,ZhuF*,DuanQ*.PhosphorylationofBCKDKofBCAAcatabolismatY246bySrcpromotesmetastasisof colorectal cancer. Oncogene. 2020May;39(20):3980-3996. (IF=7.485)
10.LuH,XiaoJ,KeC,NiX,XiuR,TianQ,PanH,ZouL,WangF,MaT,JiX,YuanP,LiuL,ZhangJ,JiaW*, DuanQ*,ZhuF*.TOPKinhibitsautophagybyphosphorylatingULK1andpromotesgliomaresistancetoTMZ. Cell Death Dis. 2019 Aug5;10(8):583. (IF=8.469)
11.FuY,YangG,XueP,GuoL,YinY,YeZ,PengS,QinY,DuanQ,ZhuF.Dasatinibreduces5-Fu-triggered apoptosis in colon carcinoma by directly modulating Src-dependent caspase-9 phosphorylation. Cell DeathDiscov.2018 May 23; 4:61. doi:10.1038/s41420-018-0062-5. (IF=5.241)
12.PeipeiXue#,FanfanZeng#,QiuhongDuan#,JuanjuanXiao1,LinLiu1,PingYuan,LinniFan,HuiminSun, OlesyaMalyarenko,HuiLu,RuijuanXiu,ShaoqingLiu,ChenShao,JianminZhang,WeiYan*,ZheWang*,JianyongZheng*,FengZhu*.BCKDKofBCAAcatabolismcross-talkingwiththeMAPKpathwaypromotes tumorigenesis of colorectalcancer.Ebiomedicine,2017;20:50-60. (IF=8.143)
13.ChuntaoQuan#,JuanjuanXiao#,LinLiu,QiuhongDuan,PingYuan*,FengZhu*.Proteinkinasesastumor biomarkers and therapeutic targets. Curr Pharm Des. 2017, 23(46):4209-4225. (IF=3.452)
14.Olesia S. Vishchuk#, Huimin Sun#, Zhe Wang, Svetlana P. Ermakova, JuanJuan Xiao, Tao Lu, PeiPei Xue, Tatyana N. Zvyagintseva, Hua Xiong, Chen Shao, Wei Yan*, Qiuhong Duan*, Feng Zhu*. PDZ-Binding Kinase/T- LAK Cell-Originated Protein Kinase is a target of the fucoidan from brown alga Fucus evanescens in the prevention of EGF-induced neoplastic cell transformation and colon cancer growth. Oncotarget, 2016;7(14):18763-73. （IF=6.359)
第一作者的论文
1.Zykova T#, Zhu F#, Wang L, Li H, Lim DY, Yao K, Roh E, Yoon SP, Kim HG, Bae KB, Wen W, Shin SH, NadasJ, LiY,MaW,BodeAM,DongZ.TargetingPRPKFunctionBlocksColonCancerMetastasis.MolCancerTher. 2018May;17(5):1101-1113.doi:10.1158/1535-7163.MCT-17-0628.Epub2018Feb26. (IF=6.261)
2.Zykova TA#, Zhu F#, Wang L#, Li H#, Bai R, Lim DY, Yao K, Bode AM, Dong Z. The T-LAKCell-originated Protein Kinase Signal Pathway Promotes Colorectal Cancer Metastasis. EBioMedicine. 2017; 18:73-82.(IF=8.143)
3.LiH#,ZhuF#,BoardmanLA,WangL,OiN,LiuK,LiX,FuY,LimburgPJ,BodeAM,DongZ.AspirinPrevents Colorectal Cancer by Normalizing EGFR Expression. EBioMedicine. 2015, 2(5):447-455.. (IF=8.143)
4.Li H#, Zhu F#, Chen H, Cheng KW, Zykova T, Oi N, Lubet RA, Bode AM, Wang M, Dong Z.6-C-(E- phenylethenyl)-naringenin suppresses colorectal cancer growth by inhibiting cyclooxygenase-1. CancerRes. 2014,74(1):243-252. (IF=12.701)
5.XieH#,LeeMH#,ZhuF#,ReddyK,HuangZ,KimDJ,LiY,PengC,LimdoY,KangS,JungSK,LiX,LiH, Ma W, Lubet RA, Ding J, Bode AM, Dong Z. Discovery of the novel mTOR inhibitor and its antitumoractivities in vitro and in vivo. Mol Cancer Ther.2013,12(6):950-8. （IF=5.683)
6.Xie H#, Lee MH#, Zhu F#, Reddy K1, Peng C, Li Y, Lim do Y, Joon Kim D, Li X, Kang S, Li H, Ma W, LubetRA, DingJ,BodeAM,DongZ.IdentificationofanaurorakinaseinhibitorspecificfortheauroraBisoform.CancerRes. 2013,73(2):716-24. (IF=12.701)
7. Li X#, Li H#, Li S#, Zhu F#, Kim DJ, Xie H, Li Y, Nadas J, Oi N, Zykova TA, Yu DH, Lee MH, Kim MO, Wang L,MaW,LubetRA,BodeAM,DongZ,DongZ.Ceftriaxone,anFDA-approvedcephalosporinantibiotic, suppresseslungcancergrowthbytargetingAuroraB.Carcinogenesis.2012,33(12):2548-57. (IF=5.334)
8. Xie H#, Zhu F#, Huang Z, Lee MH, Kim DJ, Li X, Lim do Y, Jung SK, Kang S, Li H, Reddy K, Wang L, MaW, LubetRA,BodeAM,DongZ.Identificationofmammaliantargetofrapamycinasadirecttargetoffenretinide both in vitro and in vivo. Carcinogenesis.2012,33(9):1814-21. (IF=5.334)
9.ZhangJ#,ZhuF#,LiX,DongZ,XuY,PengC,YaoK,ZykovaTA,BodeAM,DongZ.Rack1protectsN- terminal phosphorylated c-Jun from Fbw7-mediated degradation. Oncogene. 2012,31(14):1835-44.(IF=7.485)
10.Li S#, Zhu F#, Zykova T, Kim MO, Cho YY, Ma W, Carper A, Langfald A, Dong Z. T-LAK cell-originatedproteinkinase(TOPK)phosphorylationofMKP1proteinpreventssolarultravioletlight-inducedinflammationthrough inhibition of the p38 protein signaling pathway. J Biol Chem.2011,286(34):29601-9. (IF=4.573)
11.LiX#,WenW#,LiuK#,ZhuF#,MalakhovaM,PengC,LiT,KimHG,MaW,ChoYY,BodeAM,DongZ, DongZ.Phosphorylationofcaspase-7byp21-activatedproteinkinase(PAK)2inhibitschemotherapeuticdrug- inducedapoptosisofbreastcancercelllines.JBiolChem.2011,286(25):22291-9. (IF=4.573)
12.LiS#,BodeAM#,ZhuF#,LiuK,ZhangJ,KimMO,ReddyK,ZykovaT,MaWY,CarperAL,LangfaldAK,Dong Z. TRPV1-antagonist AMG9810 promotes mouse skin tumorigenesis through EGFR/Aktsignaling. Carcinogenesis.2011,32(5):779-85 (IF=5.334)
13.Li T#, Zhang J#, Zhu F#, Wen W, Zykova T, Li X, Liu K, Peng C, Ma W, Shi G, Dong Z, Bode AM, Dong Z.P21- activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes celltransformation. Carcinogenesis.2011,32(5):659-66. (IF=5.334)
14.Zhu F#, Zykova TA#, Peng C, Zhang J, Cho YY, Zheng D, Yao K, Ma WY, Lau AT, Bode AM, Dong Z. Phosphorylation of H2AX at Ser139 and a new phosphorylation site Ser16 by RSK2 decreases H2AX ubiquitination and inhibits cell transformation. Cancer Res. 2011,71(2):393-403.(IF=12.701)
