团队贡献及规划：

1. 对期刊GPD的贡献和规划：

   作为通讯作者在GPD期刊已经发表3篇文章，其中综述2篇，研究性论文1篇，目前正在撰写2篇，计划未来1-5年投稿5篇。

2. 对核蛋白PCNP研究的贡献和规划：

目前已开展核蛋白PCNP研究，已完成PCNP泛癌分析，目前在肝细胞肝癌、胶质瘤等疾病中进一步探究PCNP的预后价值及靶向治疗作用，并已取得阶段性进展。

3. 对团队论文的贡献和规划：

   未来1-5年计划以团队名义在GPD杂志投稿并发表3-5篇文章。

4. 对合作医院项目的贡献和规划：

未来1-5年计划与医院合作在GPD杂志投稿并发表3-5篇文章。

已于3月到三门峡黄河医院进行交流学习。

计划到郑州市澍青、滑县人民医院等合作单位交流学习。

5. 对留学生、研究生和本科生培养的贡献和规划：

   已培养大量本科生，为临床医学输送大量优秀人才。已培养多名研究生顺利毕业，获得硕士学位，参加工作或继续深造博士研究生。

6. 未来1-5年的科研规划：

   重点开展核蛋白PCNP研究，完成PCNP及其信号通路分子在肝细胞肝癌、胶质瘤等疾病中的预后及靶向治疗作用与分子机制研究。

个人简历

安杨，副教授，博士，硕士研究生导师。中国微循环学会转化医学专业委员会青年委员，河南省抗癌协会肿瘤临床精准诊断与治疗专业委员会委员，河南省生物化学与分子生物学学会理事，Gene & Protein in Disease杂志青年编委。2013年入职河南大学基础医学院，在生物化学与分子生物学教研室从事教学工作，承担本科生《生物化学与分子生物学》、《神经生物学》、《分子生物学实验技术》和研究生《基因工程》等教学工作，并开设有特色课程—本科生拓展性实验课《实时荧光定量PCR》和《Western blotting》，旨在提升学生的动手操作能力和科研思维。作为指导教师指导12项大学生创新创业训练计划项目（其中6项国家级和4项校级项目均已顺利结题）和大学生科学研究类竞赛（获得一、二、三等奖）。指导多名本科生进行科研训练和毕业设计，获得奖学金、保研名额、顺利毕业。荣获第三届中部三省（河南、湖北、湖南）生物化学与分子生物学教学微课赛二等奖。

科研方面，先后在学术杂志上发表多篇SCI论文，主持和参与多项科研项目。在河南大学工作期间发表SCI论文31篇，其中第一及通讯作者论文11篇，一区1篇，二区6篇，三区3篇，四区1篇。主持1项河南省重点研发与推广专项（科技攻关）项目（已结题）。主持1项河南省高等学校重点科研项目（已结题），主持1项河南大学科学研究基金项目（已结题）。获得河南省教育厅科技成果奖二等奖。指导多名研究生开展学术课题、掌握实验技术、撰写毕业论文并顺利取得硕士学位、获得奖学金等。

发表SCI论文：

(1) Lu Xiaoyan^#, Zhang Yuanyuan^#, Yang Pei, Yi Minjun, Wang Luyao, Chen Jing, Wang Han, Li Mengke, Jiang Yufei, Guo Bingbing, Lu Wenyuan, Li Shijia, Chen Jiahao, Lian Yingying, Li Xinyu, Zhao Binbin, Wang Xiaoqing*, An Yang*. Comprehensive prognostic signatures in thyroid cancer-review for molecular signatures construction strategies. Gene & Protein in Disease. 2023, 2(3):1138.（通讯作者）

(2) Li Xinyu^#, Wu Jialin^#, Yue Man, Hou Mengwen, Han Jiayang, Zhao Binbin, Sun Tiantian, Han Xu, Liu Guangchao, Zhang Kaifeng, Wu Tinggai, Ye Ting, Tu Mengjie, An Yang*. High expression of apoptosis-related LMNB2 predicts an unfavorable outcome: A potential prognostic biomarker for liposarcoma. Gene & Protein in Disease. 2024, 3(1): 2607.（通讯作者）

(3) Li Jiali^#, Pan Yanbing^#, Tu Mengjie, Han Jiayang, Zhao Binbin, Wu Jialin, Liu Guangchao, Zhang Kaifeng, Yue Man, Hou Mengwen, Sun Tiantian, Han Xu, Chen Kangxu, An Yang*. Zinc finger protein 521 (ZNF521/Zfp521): insights into its structure, function, regulation and significance to cell differentiation. Gene & Protein in Disease. 2024. In press.（通讯作者）

(4) Guo Ge^#, Wang Wanli^#, Tu Mengjie, Zhao Binbin, Han Jiayang, Li Jiali, Pan Yanbing, Zhou Jie, Ma Wen, Liu Yi, Sun Tiantian, Han Xu, An Yang*. Deciphering adipose development: Function, differentiation and regulation. Developmental Dynamics. 2024, 1-42. doi: 10.1002/dvdy.708. Online ahead of print.（通讯作者）

(5) Sun Leilei, Ji Shaoping, Xie Xuan, Si Lei, Liu Shaohao, Lin Yao, Wang Yahui, Song Zhenhua, Fang Na, An Yang*, Yang Jian*. Deciphering the interaction between Twist1 and PPARγ during adipocyte differentiation. Cell Death & Disease. 2023: 14(11):764.（通讯作者）

(6) An Yang^#*, Lu Wenyuan^#, Li Shijia, Lu Xiaoyan, Zhang Yuanyuan, Han Dongcheng, Su Dingyuan, Jia Jiaxin, Yuan Jiaxin, Zhao Binbin, Tu Mengjie, Li Xinyu, Wang Xiaoqing, Fang Na*, Ji Shaoping*. Systematic review and integrated analysis of prognostic gene signatures for prostate cancer patients. Discover Oncology. 2023: 14: 234.（第一及通讯作者）

(7) Chen Jiahao^#; Lian Yingying^#; Zhao Binbin; Han Jiayang; Li Xinyu; Wu Jialin; Hou Mengwen; Yue Man; Zhang Kaifeng; Liu Guangchao; Tu Mengjie; Ruan Weimin; Ji Shaoping; An Yang*; Deciphering the Prognostic and Therapeutic Significance of Cell Cycle Regulator CENPF: A Potential Biomarker of Prognosis and Immune Microenvironment for Patients with Liposarcoma, International Journal of Molecular Sciences. 2023, 24(8): 7010.（通讯作者）

(8) Wang Xiangze, Zhao Minghui, Zhang Chensheng, Chen Haobo, Liu Xingyu, An Yang, Zhang Lu*, Guo Xiangqian*. Establishment and Clinical Application of the Nomogram Related to Risk or Prognosis of Hepatocellular Carcinoma: A Review. Journal of Hepatocellular Carcinoma. 2023, 10: 1389-1398.

(9) Liu Yanjie^#; Zhang Dongya^#; An Yang; Sun Yajing; Li Jia; Zheng Meng; Zou Yan*, Shi Bingyang*; Non-invasive PTEN mRNA brain delivery effectively mitigates growth of orthotopic glioblastoma, Nano Today, 2023, 49: 101790.

(10) Ruan Weimin^#; Jiao Mingzhu^#; Xu Sen^#; Ismail Muhammad; Xie Xuan; An Yang; Guo Haixing; Qian Rongjun*; Shi Bingyang*; Zheng Meng*; Brain-targeted CRISPR/Cas9 nanomedicine for effective glioblastoma therapy, Journal of Controlled Release, 2022, 351: 739–751.

(11) An Yang^#; Wang Qiang^#; Zhang Guosen; Sun Fengjie; Zhang Lu; Li Haojie; Li Yingkun; Peng Yanyu; Zhu Wan; Ji Shaoping; Guo Xiangqian*; OSlihc: An Online Prognostic Biomarker Analysis Tool for Hepatocellular Carcinoma, Frontiers in Pharmacology, 2020, 11: 875.（第一作者）

(12) An Yang^#; Wang Qiang^#; Zhang Lu; Sun Fengjie; Zhang Guosen; Huan Dong; Li Yingkun; Peng Yanyu; Li Haojie; Zhu Wan; Ji Shaoping; Wang Yunlong*; Guo Xiangqian*; OSlgg: An Online Prognostic Biomarker Analysis Tool for Low-Grade Glioma, Frontiers in Oncology, 2020, 10: 1097.（第一作者）

(13) An Yang^#; Wang Qiang^#; Sun Fengjie; Zhang Guosen; Wang Fengling; Zhang Lu; Li Yanan; Ren Weinan; Zhu Wan; Li Yongqiang; Ji Shaoping; Guo Xiangqian*; OSucs: An Online Prognostic Biomarker Analysis Tool for Uterine Carcinosarcoma, Genes, 2020, 11(9): 1040.（第一作者）

(14) Wang Qiang^#; An Yang^#; Wang Fengling; Zhang Guosen; Zhang Lu; Huan Dong; Xin Junfang; Li Yongqiang; Ji Shaoping; Guo Xiangqian*; OSchol: an online consensus survival web server for cholangiocarcinoma prognosis analysis, HPB, 2020, HPB (Oxford), 2021, 23(4): 545-550.

(15) Zhang Guosen, An Yang, Zhang Lu, Xie Longxiang, Guo Xiangqian*; Risk factors for in-hospital mortality in patients with cancer and COVID-19, Lancet Oncology, 2020, 21(9): e407.（第一作者）

(16) Ruan Weimin; Zheng Meng*; An Yang; Liu Yuanyuan; Lovejoy David B; Hao Mingcong; Zou Yan; Lee Albert; Yang Shu; Lu Yiqing; Morsch Marco; Chung Roger; Shi Bingyang*; DNA nanoclew templated spherical nucleic acid for siRNA delivery, Chemical Communications, 2018, 54(29): 3609-3612.

(17) Xiao Man; An Yang; Wang Fengling; Yao Chao; Zhang Chu; Xin Junfang; Duan Yongjian; Zhao Xiaofang; Fang Na*; Ji Shaoping*; A chimeric protein PTEN-L-p53 enters U251 cells to repress proliferation and invasion, Experimental Cell Research, 2018, 369(2): 234-242.

(18) An Yang^#; Wang Shuzhen^#; Li Songlin; Zhang Lulu; Wang Dayong; Wang Haojie; Zhu Shibai; Zhu Wan; Li Yongqiang; Chen Wenwu; Ji Shaoping*; Guo Xiangqian*; Distinct molecular subtypes of uterine leiomyosarcoma respond differently to chemotherapy treatment, BMC Cancer, 2017, 17: 639-646.（第一作者）

(19) An Yang; Furber Kendra L; Ji Shaoping*; Pseudogenes regulate parental gene expression via ceRNA network, Journal of Cellular and Molecular Medicine, 2017, 21(1): 185-192.（第一作者）